| |
HCV |
HBV |
| Viral components modulating host responses |
Viral RNA,Core NS5A, NS3,NS4B(Ref 27, 28) |
Viral dsDNA,I-IBX, I-IBsAg, I-lBeAg
(Ref 72-75, 77, 110) |
| Altered host pathways |
RIG, MAPK, JNK, Wnt/B-catenin, Akt/mTOR, JAK-STAT,
(Ref 23, 25)
|
JNK, Pyk2, MAPK, Wnt, Ras, P13K/Akt, c-Raf-1/Erk2(Ref 3l, 34, 77, 85) |
| Key up-regulated molecules
|
TGF-b, TNF-a, AP1,STAT3, c-jun,NFҝB,TRIP, IRF-3/IRF-7, ISGs,(Ref 24, 25, 49, 66) |
AP1,NF-AT,NFҝB, Erb2, SOCS3, ISGs(Ref 30, 34) |
| miRNAs
|
↑ miR-449a, miR-107, miR-155, miR146a ↓
miR-l25b(Ref 5, 49) |
↑ miR-155, miR-210
↓miR-29 family(Ref 50, 51) |
|
