Figure 3: Sequence variants of MEFV gene (NM_000243.2). The 10 exons on chromosome 16p13.3 are shown, with the sequence variant usual names. MEFV encodes a 781 amino acid (86kDa) protein (pyrin or marenostrin). In FMF, pyrin function is dysregulated with abnormal transcription of intranuclear peptides involved in inflammation. See text for further details. From INFEVERS — INternet periodic FEVERS — website: an online database for autoinflammatory mutationCopyright. Accessed 08-03-2014 [84-86]. Available at http://fmf.igh.cnrs.fr/ISSAID/infevers/.