Patients Dosing** Adults 1.2-2.4 mg/day p.o. in 1-2 divided doses The dose can be increased or decreased in 0.3 mg/day amount based on efficacy or adverse effects Children 4-6 years 0.3-1.8 mg/day in 1-2 divided doses Children 7-12 years 0.9-1.8 mg/day in 1-2 divided doses Children >12 years Adult dosing

Table 2: Recommended dosing of colchicine* in symptomatic Familial Mediterranean Fever [4]. *approved by FDA in USA in october 2009 for use in FMF patients [99]; **dosing to be adjusted in case of renal impairment and in case of dialysis (cholchicine is NOT removed). Contraindications exist during renal or hepatic impairment for combined colchicine and P-glycoprotein or strong CYP3A4 inhibitors. Dosing to be adjusted for concomitant therapy with P-glycoprotein inhibitors (eg, cyclosporine, ranolazine) or CYP3A4 inhibitors (strong: clarithromycin, ketoconazole, atazanavir, darunavir, indinavir, itraconazole, lopinavir/ritonavir, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, tipranavir; moderate: erythromycin, fluconazole, grapefruit juice, verapamil, diltiazem, aprepitant, fosamprenavir).