DIAGNOSIS   FAMILIAL RELATIONSHIP Number (males, females)   FAMILIES vs. NORMAL   Table 2 Table 3 Total Rate of ML (%) Ratio males, females         families normal families normal HL 6 (5,1) 5 (3,2) 11 (8,3) 21 10 2.7 1.5 FL 3 (3,0) 6 (3,3) 9 (6,3) 17 20-25 2.0 1.1 DLBCL 8 (5,3) 4 (2,2) 12 (7,5) 23 30-35 1.4 1.2 LPL 3 (2,1) 3 (1,2) 6 (3,3)         BL 2 (0,2) 2 (2,0) 4 (2,2)     T 1 (1,0) 1 (1,0) 2 (2,0)     MCL   1 (1,0) 1 (1,0)     MZL 1 (1,0) 2 (2,0) 3 (3,0)     NOS 2 (0,2) 2 (2,0) 4 (2,2)     NHL 20 (12,8) 21 (14,7) 41 (26,15) 38 35 1.7 1.3 HL & NHL 26 (17,9) 26 (17,9) 52 (34,18) 100 100 1.9 1.2             CLL 22 (14,8) 15 (10,5) 37 (24,13)   1.9 1.9 LGTCL   2 (1,1) 2 (1,1)     T PLL   1 (0,1) 1 (0,1)     MM 3 (3,0) 2 (1,1) 5 (4,1)   4.0 1.4             AML   1 (0,1) 1 (0,1)     CML   1 (0,1) 1 (0,1)     MF   1 (0,1) 1 (0,1)     ET   1 (1,0) 1 (1,0)                 Patients 51 (34,17) 50 (30,20) 101 (64,37)

Families 22 21 43   Generations 45 41 86   Patrilineal 13 3 16   Matrilineal 7 9 16   Patri- and matrilineal 2   2

Abbreviations: HL Hodgkin’s lymphoma; FL follicular lymphoma grade I-III; DLBCL diffuse large B-cell lymphoma; LPL lymphoplasmocytic lymphoma; BL Burkitt’s lymphoma; T Precursor T-lymphoblastic lymphoma; MCL mantle cell lymphoma; MZL marginal zone B-cell lymphoma; NOS not otherwise specified; NHL non-Hodgkin’s lymphoma, CLL chronic lymphocytic leukemia; LGTCL large granular T-cell leukemia; T PLL T-cell prolymphocytic leukemia; MM multiple myeloma; AML acute myeloblastic leukemia; CML chronic myeloid leukemia, MF myelofibrosis; ET essential thrombocytopenia

Table 1: Malignant hematological disorders in 43 families with malignant lymphoma.