| GRAND PARENT – PARENT – OFFSPRING |
| Family number |
Combination |
Diagnosis and age at onset (years) |
Birth order |
| 10 |
Grand father-father-son |
CLL 72 – CLL 58 – HL 32 |
4/7, 2/3, 2/2 |
| 10 |
Father’s sister |
CLL 61 |
3/3 |
| 35 |
Grand mother – mother - son |
CLL 71 – FL 61 – HL 36 |
US, 1/1, ½ |
| 95 |
Grand mother – mother - son |
CLL 86 – normal – BL 21 |
US, 2/4, ¼ |
| 96 |
Grand mother – mother - son |
T PLL 42 – normal – NOS 36 |
1/6, 1/4, 2/2 |
| 37 |
Grand mother – mother - daughter |
MM 79 – LPL 56 – FL 42 |
US, 1/3, ½ |
| Age at onset, grandparent – parent and parent - offspring P = 0.004 |
Birth order effect 6A (95%CI): 114 (100-176) ,P > 0.05 (Haldane Smith test) |
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| UNCLE, AUNT – NEPHEW, NIECE, COUSIN |
| Family number |
Combination |
Diagnosis and sex
(m male, f female) |
Evaluable sibships (n) and Birth order |
| 77 |
Proband – brother’s daughter |
DLBCLm – CLLf |
(2) 3/3, 3/3 |
| 89 |
Proband – brother’s son |
HLm – CLLm |
(2) 2/3, 2/4 |
| 89 |
Proband’s brother |
MMm |
3/3 |
| 76 |
Proband – mothers’s sister’s son |
FLf – CLLm |
(2) 1/1, 1/3 |
| 78H |
Proband – son |
DLBCLf – CLLm |
(2) 1/2, 1/2 |
| 78H |
Proband’s sister |
AMLf |
2/2 |
| 102 |
Proband –mother’s sister’s son |
DLBCLf – CLLm |
(2) 1/2, 5/7 |
| 102 |
Proband’s brother |
FLm |
2/2 |
| 104 |
Proband – mother’s sister |
MCLm – CMLf |
(1) 2/2, US |
| 104 |
Proband’s brother |
CLLm |
½ |
| 108 |
Proband –mother’s brother’s son |
Tm – CLLm |
(2) 4/5, 3/4 |
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222 (158-244) P> 0.05 |
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| SIB CONCORDANCE |
| Combination and birth order |
| Family number |
Brother – Brother |
Family number |
Sister – Brother |
| 78B |
LPL – LGTCL 1/4 , 4/4 |
79B |
LGTCL – FL 2/3, 3/3 |
| 85 |
BL – CLL 1/3, 2/3 |
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| 82B |
MZL – FL 2/3, 3/3 |
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Sister – Sister |
| 81B |
ET – DLBCL 1/2 , 2/2 |
61 |
HL - HL 1/3, 3/3 |
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Brother – Sister |
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| 83 B |
MZL –MF 1/3, 2/3 |
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| 58 |
NOS – CLL 1/2 , 2/2 |
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| 79A |
CLL – LPL 1/4, 4/4 |
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