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Figure 1: Higher expression of LSF in human melanocytic nevi than in melanomas. (a-f) Immunohistochemical detection of LSF in a tissue array. Representative signal scores for both nevus (a-c) and melanoma (d-f) samples are shown as negative/weak (a and d), moderate (b and e), and strong (c and f). Arrows mark the area magnified in the inset. Scale bar, 200μm. (g) Relative proportion of each scoring group in benign nevi, primary and metastatic melanomas. All samples examined were classified into three groups based on the signal intensity. Asterisks indicate a significant difference between groups (**P<0.01). |