CHIN ET AL (7) JENNI ET AL (48) STOLLBERGER ET AL (49) PETERSEN ET AL (61) JACQUIER ET AL (63) STACEY ET AL (66)
Imaging modality TTE TTE TTE Cardiac MRI Cardiac MRI Cardiac MRI
Quantitative criteria Quotient of the  distance from epicardial surface to trough of trabecular recess (X) and distance from epicardial surface to peak of trabeculation (Y) ≤ 0.5 Non-compacted to compacted segment ratio > 2.0 > 3 trabeculations from apex to papillary muscle in 1 imaging plane Non-compacted to compacted segment ratio of >2.3 LV trabecular mass >20% of total LV mass Non-compacted to compacted ratio of >2
Qualitative features No co-existing cardiac anomalies, progressive increase in Y from base to apex No co-existing cardiac anomalies, 2 layered myocardium, intertrabecular recesses communicate with LV cavity demonstrated by color flow Doppler Intertrabecular recesses communicate with LV cavity by color flow Doppler, 2 layered myocardium 2 layered myocardium 2 layered  myocardium 2 layered myocardium
Anatomic focus of measurement Base, papillary muscles, and apex Mid-lateral, mid-inferior, apex Apex, lateral, inferior walls All of LV All of LV All of LV
Views Parasternal long axis, apical 4-chamber, subxyphoid Parasternal short axis Various Long axis Short axis Short axis
Cardiac phase End-diastole End-systole Not applicable Diastole End diastole End systole
Supporting data 8 patients with LVNC compared to 8 controls found to differ significantly 7 patients with LVNC , TTE correlated to autopsy findings, differentiated patients from 19 LVH and/or DCM controls No rigorous validation 7 patients with LVNC differentiated from 125 subjects with HCM, DCM, hypertensive heart disease, aortic stenosis, and athletes 16 patients with LVNC differentiated from 48 HCM, DCM, and healthy controls Associated with higher hazard ratio of clinical events than Petersen, Jacquier criteria
Sensitivity/Specificity None documented None documented None documented 86%/99% 93.7%/93.7% None documented
Limitations No sensitivity/specificity data, few patients studied No sensitivity/specificity data, few patients studied No rigorous validation May lack specificity in lower pretest probability patients Interobserver reproducibility of LV trabeculated mass is potentially poor New criteria, unknown reproducibility of findings
Table 2: Diagnostic Criteria for LVNC.