Figure 2: Sequence alignment of MetAPs from E. coli (accession #P0AE18), M. tuberculosis (accession #P9WK19), human MetAPI (accession #P53582), human mitochondrial MetAP (accession #Q6UB28), rat MetAPII (accession #P38062) and human MetAPII (accession #P50579). The basic and acidic motifs are underlined, the metal binding residues are shown in pink, highly conserved residues (cyan), Cys (blue), Met (forest), His (firebrick); the same colors were used in the 3D structures of human MetAPI and MetAPII. ClustalO (UniProt) was used for the alignment.