Figure 3: Human IgG antibodies. A. Schematic representation of IgG2 with disulfide bonding, originally proposed (left) and observed rearrangements (right, dotted red lines), B. Schematic representation of IgG4 with disulfide bonding, originally proposed (left) and observed rearrangements (right, dotted red lines). C. Structure of intact monoclonal IgG2ak antibody (PDB 1IGT) with the two heavy chains (red and blue) and the two light chains (pink and light blue) such as colored in the scheme. D. The hinge region of IgG2ak with the disulfide bonds formed between the light and the heavy chains (CL214-CH128), and between the two heavy chains: CH237-CH237, CH240-CH240 and CH242-CH242. Data used from Ref. [70-72] and PyMOL was used for drawing the figures.