| Taxonomy, Organism |
Isoform |
3Ds # |
Cys # |
Met # |
His
# |
Me2+ in the active site |
Other metal ions
(# of structures) |
Selected PDB Ids |
| Bacterial |
|
67 |
|
|
|
|
Na+ (42), K+ (5) Mn2+ (3) in NXV |
|
| Escherichia coli |
MetAPIa |
41 |
7 |
8 |
9 |
1Mn2+
2Mn2+
3Mn2+
2Co2+
3Co2+ |
Na+ in NXV (39), Co2+ on the surface bound to 54H (2) and 122E (1) |
2P99, 2Q92, 2BB7, 1MAT, 2EVO, 1YVM, 2MAT, 4PNC |
| Mycobacterium tuberculosis |
MetAPIb |
14 |
4 |
6 |
8 |
2Mn2+ 2Co2+
2Ni2+
3Ni2+ |
K+ in NXV (5) |
1YJ3, 3PKA, 3IU8, 3IU9, 3PKA |
| Mycobacterium abscessus |
MetAPIa |
1 |
2 |
7 |
8 |
2Mg2+ |
Na+ in NXXV |
3TAV |
| Pseudomonas aeruginosa |
MetAPIa |
3 |
6 |
7 |
11 |
2Mn2+ |
Mn2+ in NXV (3), Mn2+ in the interface bound to 144H (3) |
4FO7, 4FO8, 4JUQ |
| Staphyloccocus aureus |
MetAPIb |
3 |
3 |
5 |
7 |
2Co2+
3Co2+ |
N/A |
1QXW, 1QXY, 1QXZ |
| Streptococcus pneumoniae |
MetAPIa |
1 |
5 |
14 |
7 |
N/A |
N/A |
4KM3 |
| Rickettsia prowazekii |
MetAPIa |
2 |
3 |
7 |
10 |
2Mn2+ |
Na+ in NXV (2) |
3MR1, 3MX6 |
| Enterococcus faecalis |
MetAPIa |
1 |
6 |
9 |
9 |
N/A |
N/A |
3TB5 |
| Thermotoga maritima |
MetAPIa |
1 |
3 |
5 |
6 |
N/A |
N/A |
1O0X |
| Archaea |
|
6 |
|
|
|
|
|
|
| Pyrococcus furiosus |
MetAPII |
6 |
0 |
9 |
6 |
2Mn2+
2Co2+
3Co2+ |
N/A |
1XGM, 1XGN, 1XGO, 1XGS, 1WKM, 2DFI |
| Protista |
|
1 |
|
|
|
|
|
|
| Trypanosoma brucei |
MetAPIc |
1 |
15 |
9 |
14 |
2Zn2+ |
unknown ions |
4FUK |
| Eukaryota |
|
39 |
|
|
|
|
|
|
| Plasmodium falciparum |
MetAPIc |
1 |
13 |
7 |
19 |
1Fe3+ |
N/A |
3S6B |
| Encephalitozoon cuniculi |
MetAPII |
3 |
5 |
8 |
10 |
2Fe3+ |
N/A |
3FM3, 3FMQ, 3FMR |
| Human |
MetAPIc |
17 |
15 |
9 |
16 |
2Mn2+ 2Co2+ 3Co2+ |
K+, Na+, Ca2+ in NXV (12, 4, 1) |
4FLJ, 2B3K, 2G6P, 2GZ5, 2NQ6 |
| Human |
MetAPII |
18 |
15 |
9 |
11 |
2Mn2+ 2Co2+
2Zn2+ |
disulfide (17) |
2EA2, 1BOA, 1KQ0 |
|
