| Strategy |
FVIIa |
FIX |
FX/FXa |
| Increased activity |
[4,10,16-22,24,35] |
[37,40-42,44-46] |
/ |
| Affected membrane affinity |
[5,25-27] |
[42,48] |
/ |
| Prolonged half-life |
[28-30] |
[62-64] |
[65,71,74,75] |
| FVIII bypass activity |
/ |
[56-59] |
/ |
| Thrombin- / auto-activable |
/ |
/ |
[66,77,78] |
|
