Saquinavir Ritonavir Indinavir Nelfinavir Amprenavir Lopinavir Atazanavir Fosamprenavir Tipranavir Darunavir Saquinavir 1.00 0.54 0.59 0.57 0.50 0.57 0.61 0.52 0.45 0.50 Ritonavir 0.54 1.00 0.51 0.44 0.52 0.59 0.55 0.55 0.52 0.55 Indinavir 0.59 0.51 1.00 0.53 0.45 0.52 0.54 0.46 0.42 0.45 Nelfinavir 0.57 0.44 0.53 1.00 0.45 0.52 0.47 0.46 0.40 0.46 Amprenavir 0.50 0.52 0.45 0.45 1.00 0.48 0.51 0.87 0.49 0.89 Lopinavir 0.57 0.59 0.52 0.52 0.48 1.00 0.55 0.48 0.41 0.49 Atazanavir 0.61 0.55 0.54 0.47 0.51 0.55 1.00 0.53 0.47 0.53 Fosamprenavir 0.52 0.55 0.46 0.46 0.87 0.48 0.53 1.00 0.53 0.81 Tipranavir 0.45 0.52 0.42 0.40 0.49 0.41 0.47 0.53 1.00 0.54 Darunavir 0.50 0.55 0.45 0.46 0.89 0.49 0.53 0.81 0.54 1.00

Table 1: Tanimoto similarity scores between usual ARVs extracted from HIV-PDI. High scores represent high similarities. Here compound highly similar to amprenavir are highlighted in grey.