Interactions present in all 14 Indinavir PDB complex structures presently available in HIV-PDI Interactions present in all 10 Nelfinavir PDB complex structures presently available in HIV-PDI Interactions present in all 14 Saquinavir PDB complex structures presently available in HIV-PDI Residue Number ALA 28A ALA 28B ARG 8A ASP 25A ASP 25B ASP 29A ASP 29B ASP 30A ASP 30B GLY 27A GLY 27B GLY 48A GLY 48B GLY 49A GLY 49B LEU 23A LEU 23B PRO 81A PRO 81B Residue Number ALA 28A ALA 28B ARG 8B ASP 25A ASP 25B ASP 29A GLY 27A GLY 27B GLY 49B ILE 47A ILE 47B ILE 50A ILE 50B LEU 23A LEU 23B PRO 81A PRO 81B VAL 32A VAL 32B Residue Number ALA 28A ASP 25A ASP 29A ASP 30A GLY 27A GLY 49A ILE 47A LEU 23A PRO 81A

Table 8: Critical residues involved in ARV interactions and characterized in the crystal HIV-1 proteases from HIV-PDI database. Critical residues involved in ARV interactions and characterized in the crystal HIV-1 proteases from HIV-PDI database in complex with indinavir, nelfinavir, and saquinavir, respectively.