Figure 6: Fragmentation and 1st and 2nd cleavage. After syngamy, the first cleavage furrow appeared (a) During first cleavage, some fragments were generated along the furrow (b) but the number of fragments decreased about 2.5 hours later (c) About 10 hours later, the second cleavage furrow appeared (d) and the blastomere shape degraded into poor quality during the middle of the second cleavage (e) However, about 6 hours later, the embryo developed into good quality.