S.No R1 R2 IC50 (μM)] pIC50 1 H 30.6 4.5142 2 –CH2CH2OH 131 3.8827 3 4.06 5.3914 4 0.459 6.3381 5 1.63 5.7878 6 1.76 5.7544 7 H 26 4.5850 8* –CH2CH2OH 90.7 4.0423 9 28.6 4.5436 10 3.72 5.4294 11 9.73 5.0118 12 16.2 4.7904 13* 30.2 4.5199 14 12.3 4.9100 15 37.2 4.4294 16 21.3 4.6716 17 3.3 5.4814 18 37.7 4.4236 19* 13.4 4.8728 20 25.3 4.5968 21 22.9 4.6401 22* 16.2 4.7904 23 3.5 5.4559 24 –CH2CH2CH2OH 17.2 4.7644 25* 0.7 6.1549 26 18.4 4.7351 27 9.8 5.0087 28* 4.73 5.3251 29 –CH2CH2CH2OH 19.5 4.7099 30 18.7 4.7281 31 17.4 4.7594 32 16.9 4.7721

*Test compounds

Table 1: Structure, and biological activity of 2-substituent-1H-benzimidazole-4-carboxamide.