S.No R MIC50a PIC50 MIC50b PIC50 MIC50c PIC50 1 35 4.4559 30 4.5228 30 4.5228 2 40 4.3979 40 4.3979 55 4.2596 3 2-F 10 5.0132 10 5.0132 10 5.0132 4 2-Cl 10 5.0132 10 5.0132 10 5.0132 5 2-CF3 25 4.6020 15 4.8239 25 4.6020 6 2-OCF3 30 4.5228 25 4.6020 15 4.8239 7 2-OC6H5 40 4.3979 35 4.4559 40 4.3979 8 2-F, 6-CH3 60 4.2218 30 4.5228 50 4.3010 9 2-F, 6-CF3 55 4.2596 40 4.3979 55 4.2596 10 2-Cl, 6-CH3 40 4.3979 55 4.2596 40 4.3979 11 2-Cl, 6-CF3 40 4.3979 60 4.2218 60 4.2218 12 2-Cl, 5-CF3 55 4.2596 80 4.0969 60 4.2218 13 2-Cl, 4-CF3 35 4.4559 25 4.6020 35 4.4559 14 2-Cl, 6-F 65 4.1870 85 4.0705 40 4.3979 15 3-CF3 40 4.3979 20 4.6989 25 4.6020 16 3-Cl, 4-F 60 4.2218 85 4.0705 80 4.0969 17 3,5-F 90 4.0457 - - 95 4.0222 18 3,4-CH3 90 4.0457 - - 95 4.0222 19 4-F, 3-CH3 65 4.1870 - - 80 4.0969 20 4-isopropyl 85 4.0705 55 4.2596 90 4.0457 21 4-butyl - - 95 4.0222 -   22 4-CF3 20 4.6989 10 5.0132 15 4.8239 23 4-OCH3 15 4.8239 15 4.8239 10 5.0132 *test set aStaphylococcus aureus; b Escherichia coli;cCandida albicans

Table 1: The structures of 3,4-dihydropyrimidin-2(1H)-one urea derivatives with their activities.