The Study Group Self Antigens BK AII VEGF bFGF ISOTYPE of NATURAL ANTIBODIES IgG IgM IgG IgM IgG IgM IgG IgM Patients with osteoarthritis of the knee 689 ± 161 287 ± 84 409 ± 111 289 ± 99 669 ± 241 559 ± 198 689 ± 245 521 ± 222 100% 77% 71% 66% 59% 79% 35% 61% Healthy Individuals 501 ± 98 407 ± 115 274 ± 84 455 ± 101 471 ± 189 366 ± 181 455 ± 115 705 ± 239 Significance P value 0.0001 0.0004 0.0005 0.0001 0.0003 0.005 0.009 0.007

Table 3: Serum expression of natural antibodies against endogenous mediators.