Variables Hazard ratio (95% CI) P value White blood cell count (×103/μl)* 1.200 (1.083-1.328) <0.001 Hemoglobin (g/dl)* 0.832 (0.735-0.941) 0.003 CEA (×10 ng/ml)*† 1.001 (1.005-1.0011) <0.001 CEA (>3.27 ng/ml) 3.099 (1.509-6.367) 0.002 Cancer stage (I + II + III vs. IV) 7.318 (3.701-14.472) <0.001 Lower level of lipocalin 2 [< 116.7 (ng/ml)] 2.950 (1.475-5.899) 0.002 Albumin (g/dl)* 0.463 (0.287-0.747) 0.002 *Value was used as continuity. †Indicated increased each 1.001 Hazard ratio with respect to increase in 10 ng/ml of CEA. ‡Primary combined endpoint was defined as any cause of death or occurrence of new onset of metastasis during long-term follow-up. CI: Confidence Interval; CEA: Carcinoembryonic Antigen; CRC: Colorectal Cancer.

Table 3: Univariable Cox Regression Analysis of Predictors for Primary Combined Endpoint During Long-term Follow-up‡.