| |
Study Day 7 |
| |
Animal# |
uVol(mL) |
uCr(mg/dL) |
uCrCl(mL/min/Kg) |
uTP/uCr(mg/mg) |
| Vehicle(0.9% Saline) |
1 |
21.20 |
29.7 |
5.2 |
0.3 |
| 2 |
32.40 |
20.7 |
5.5 |
0.6 |
| 3 |
15.30 |
44.7 |
4.1 |
0.6 |
| 4 |
17.12 |
31.9 |
4.1 |
0.5 |
| 5 |
18.19 |
40.5 |
4.4 |
0.5 |
 |
20.8 ± 3.0 |
33.5 ± 4.2 |
4.7 ± 0.3 |
0.5 ± 0.1 |
| Doxorubicin(5 mg/kg/dose) |
21 |
12.46 |
50.1 |
5.7 |
0.7 |
| 22 |
12.48 |
31.3 |
3.4 |
0.8 |
| 23 |
14.14 |
68.2 |
11.4 |
0.4 |
| 24 |
11.95 |
82.6 |
6.5 |
1.4 |
| 25 |
16.02 |
66.4 |
7.0 |
2.8 |
|
13.4 ± 0.7* |
59.7 ± 8.8* |
6.8 ± 1.3 |
1.2 ± 0.4 |
| Fold Δ |
0.6 |
1.7 |
1.4 |
3.4 |
| |
Study Day 14 |
| Vehicle (0.9% Saline) |
1 |
17.37 |
47.8 |
6.3 |
0.8 |
| 2 |
28.38 |
46.5 |
10.2 |
0.9 |
| 3 |
11.38 |
43.0 |
3.5 |
0.6 |
| 4 |
9.34 |
47.1 |
2.7 |
0.7 |
| 5 |
13.45 |
40.0 |
3.8 |
0.5 |
| |
16.0 ± 3.4 |
44.9 ± 1.5 |
5.3 ± 1.4 |
0.7 ± 0.1 |
| Doxorubicin(5 mg/kg/dose) |
21 |
2.51 |
145.5 |
6.4 |
55.9 |
| 22 |
11.47 |
51.5 |
3.9 |
55.8 |
| 23 |
5.19 |
102.0 |
12.7 |
31.0 |
| 24 |
4.16 |
107.3 |
6.7 |
59.5 |
| 25 |
6.22 |
63.2 |
7.8 |
57.8 |
|
5.9 ± 1.5* |
93.9 ± 16.8* |
5.0 ± 1.0 |
52.0 ± 5.3*** |
| Fold Δ |
0.4 |
2.1 |
0.9 |
74.3 |
| Values significantly different from Vehicle (0.9% Saline) control are indicated as***p<0.001 or *p<0.05. Urinary total protein (uTP) was normalized to concurrent urinary creatinine concentrations (uCr). |
|
