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Figure 1: The aptamer selection process and sequencing results. (a) The aptamer selection process included five rounds of enrichment with EpCAM-positive cells, five rounds with primary epithelial cells, and three rounds with the recombinant EpCAM proteins. (b) Of 500,000 reads, the domain sequence accounted for 58.7% reads, while the second-most prevalent sequence accounted for 5%. |