TNF-α -857 RA, n=269(%) HC, n=233(%) Pc OR (95% CI)       CC 78 75 NS                               CT+TT 22 25 NS                               C 88 87 NS                               T 12 13 NS                               TNF-α -308       GG 97 94 NS                               AG+AA 3 6 NS                                           G 98 97 NS                               A 2 3 NS                               TNF-α -238       GG 87 76 0.004  2.01 (1.23-3.29) GA+AA 13 24 0.003  0.48 (0.29-0.79) G 93 87 0.004  1.89 (1.21-2.97) A 7 13 0.004  0.53 (0.34-0.82)

RA-Rheumatoid Arthritis, HC-Healthy Controls, OR-Odds ratio, 95% CI-95% confidence interval. Pc <0.05 is considered significant.

Table 1: Genotype and allele frequency of TNF-α promoter polymorphism in RA and HC