TNF-α-857 High titers (%) Low titers (%) P Pc OR (95% CI) Total RA n=28 n=230       CC 64 79.6 0.07 NS   CT+TT 36 20.4 0.07 NS              C 79 89 0.02 0.03 0.44 (0.21-0.97) T 21 11 0.02 0.03 2.29 (1.03-4.78) Female RA n=26 n=207       CC 65 80.8 0.07 NS 0.45 (0.18-1.24) CT+TT 35 19.2 0.07 NS   C 79 90 0.02 0.03 0.41 (0.19-0.95) T 21 10 0.02 0.03 2.44 (1.05-5.30) YORA n=28 n=216       CC 64 81 0.05 NS              CT+TT 36 19 0.05 NS              C 79 90 0.01 0.02 0.41 (0.19-0.91) T 21 10 0.01 0.02 2.47 (1.10-5.20)

RA: Rheumatoid Arthritis, HC: Healthy Controls, OR: Odds ratio, 95% CI: 95% confidence interval, YORA: Young Onset RA (onset below 55 years of age). Pc<0.05 is considered significant.

Table 3: Influence of TNF-α promoter polymorphism on the serum TNF-α levels