Time post single dosing 24 hrs 72 hrs 168 hrs Dose (mg/kg) 100 1250 1250 1250 APAP 0.51 130.43 3.92 ND APAP-Glu 0.57 217.73 12.97 ND APAP-NAC 0.39 94.47 5.16 ND APAP-Sul 11.36 350.96 73.51 ND ND = Not detected

Table 2: Total excreted APAP and APAP metabolites (mM) detected in urine by NMR analyses.