| Marker |
Other name |
Function |
Role in colon tumorigenesis |
References |
| Lgr5 |
- |
Unknown |
Prognostic factor, adenoma formation |
[10] |
| Wnt activity |
- |
Signalling pathway |
Normal colon-adenoma transition, stem phenotype maintenance |
[20] |
| CD44 |
H-CAM |
Cell adhesion, hyaluronic acid receptor |
Colony formation, xenografts growth, prognostic factor, correlation with tumor stage |
[33,35] |
| CD326 |
EpCAM |
Cell adhesion |
Tumor budding, metastatization |
[34] |
| Msi-1 |
- |
RNA-binding protein |
Association with tumor stage |
[36] |
| ALDH-1 |
- |
Detoxifyng enzime |
Resistance to alkylating agents, prognostic factor |
[37,40] |
| CD26 |
DPP4 |
Cell surface glycoprotein |
Metastatization |
[38] |
| Eph B2 |
- |
Wnt target gene |
Cell compartimentalization |
[39] |
| CD166 |
ALCAM |
Cell adhesion |
Prognostic factor |
[40] |
| CD133 |
Prominin-1 |
Cell motility and iron metabolism |
Prognostic factor |
[40,43,44] |
| CD29 |
Integrin β1 subunit |
Cell adhesion |
Colony formation |
[41] |
| CD24 |
HSA |
Cell adhesion |
Clonogenic ability, multilineage potential, correlation with invasiveness and survival |
[41,42] |
|
