Amino acids Concentration Product Drug Substance Company
L-Arginine 55 mg/mL TNKase® Human tissue plasminogen activator (tPA) Genentech
L-Arginine 35 mg/mL Activase® Human tissue plasminogen activator (tPA) Genentech
L-Glycine 21-25 mM Kogenate®FS Recombinant antihemophilic factor (rAHF) Bayer
L-Glycine 3 mM Synagis® Human monoclonal antibody MedImmune
L-Glycine 260 mM BeneFIX® Coagulation factor IX Wyeth
L-Glycine 0.17-0.34 mg/mL Nutropin® Human growth hormone (hGH) Genentech
L-Glycine 23 mg/mL Neumega® Interleukin-11 Wyeth
L- Glutamate 1 mg/mL VariVax® Varicella virus vaccine live Merck
L-Glutamate 5 mg/mL Streptase® Streptokinase Aventis
L-Histidine 55 mM Recombinate Recombinate antihemophilic factor (rAHF) Baxter
L-Histidine 18-23 mM Kogenate®FS Recombinate antihemophilic factor (rAHF) Bayer
L-Histidine 47 mM Synagis® Human monoclonal antibody MedImmune
L-Histidine 5 mM Herceptin® Human monoclonal antibody Genentech
L-Histidine 10 mM BeneFIX® Coagulation factor IX Wyeth
Table 19: Approved protein pharmaceuticals containing amino acids as excipient [141].