L (L.) majorL. (V.) panamensis SI = (CI50 / CE50 promastigotes)
L. (l.) major SI = (CI50 / CE50 promastigotes)
CI 50
(µg/mL)
CI 50
(µg/mL)
CI 50
(µg/mL)
CI 50
(µg/mL)
CE 50
(µg/mL)
CE 50
(µg/mL)
J774
Adherent U937 e
Non adherent U937
HPBM
J774
Adherent U937
Non- adherent U937
HPBM
Mangainin 1
25.3
> 50.0
> 50.0
> 50.0
> 50.0
> 50.0
0.5
1.0
1.0
1.0
0.5
1.0
1.0
1.0
Dermaseptin S1
36.7
> 50.0
46.3
49.9
24.6
25.4
1.5
2.0
1.9
2.0
1.4
2.0
1.8
2.0
Bombinin
27.4
> 50.0
25.6
30.1
26.4
< 6.3
1.0
1.9
1.0
1.1
4.4
8.0
4.1
4.8
Andropin
> 50.0
> 50.0
> 50.0
> 50.0
> 50.0
> 50.0
1.0
1.0
1.0
1.0
1.0
1.0
1.0
1.0
TAP
> 50.0
> 50.0
> 50.0
> 50.0
46.3
23.2
1.1
1.1
1.1
1.1
2.2
2.2
2.2
2.2
Cecropin B
> 50.0
> 50.0
> 50.0
> 50.0
> 50.0
> 50.0
1.0
1.0
1.0
1.0
1.0
1.0
1.0
1.0
Cecropin P1
> 50.0
> 50.0
> 50.0
> 50.0
> 50.0
> 50.0
1.0
1.0
1.0
1.0
1.0
1.0
1.0
1.0
Cecropin A
> 50.0
> 50.0
> 50.0
> 50.0
> 50.0
> 50.0
1.0
1.0
1.0
1.0
1.0
1.0
1.0
1.0
Polystes MA
> 50.0
> 50.0
> 50.0
> 50.0
> 50.0
40.7
1.0
1.0
1.0
1.0
1.2
1.2
1.2
1.2
Melittin
43.8
> 50.0
> 50.0
22.3
7.6
< 6.3
5.8
6.6
6.6
2.9
7.0
8.0
8.0
3.6
Tachyplesin I
> 50.0
> 50.0
> 50.0
> 50.0
> 50.0
42.1
1.0
1.0
1.0
1.0
1.2
1.2
1.2
1.2
Apamin
> 50.0
> 50.0
> 50.0
> 50.0
> 50.0
> 50.0
1.0
1.0
1.0
1.0
1.0
1.0
1.0
1.0
Pr-2
> 50.0
> 50.0
> 50.0
> 50.0
> 50.0
> 50.0
1.0
1.0
1.0
1.0
1.0
1.0
1.0
1.0
MP-8
34.4
> 50.0
20.9
49.6
27.0
15.9
1.3
1.9
0.8
1.8
2.2
3.1
1.3
3.1
MP-17
> 50.0
> 50.0
> 50.0
> 50.0
> 50.0
> 50.0
1.0
1.0
1.0
1.0
1.0
1.0
1.0
1.0
MP-X
35.4
> 50.0
25.1
> 50.0
49.9
> 50.0
0.7
1.0
0.5
1.0
0.7
1.0
0.5
1.0
Pentamidin isothionate
8.5
> 3.0
20.5
<3.4
<3.1
<1.5
2.7
16.1
6.6
1.1
5.7
33.3
13.7
2.3
Paromomycin sulphate
> 50.0
> 3.0
> 50.0
> 50.0
22.8
<1.5
2.2
2.2
2.2
2.2
33.3
33.3
33.3
33.3
CLIP
> 50.0
> 50.0
> 50.0
> 50.0
> 50.0
> 50.0
1.0
1.0
1.0
1.0
1.0
1.0
1.0
1.0
Table 2: The effect of antimicrobial peptides on cell viability. Promastigote forms of L. (V) panamensis and L. (L) major used for determining (IC50), (EC50) and selectivity
index (SI) after 72 hours exposure to peptides.
