(a) Control acinar cells with euchromatic nuclei (N), well-developed cisternae of rough endoplasmic reticulum (arrow heads), mitochondria and numerous electron dense secretory granules (arrows) of variable sizes in the apical part. Scale bar=1 lm.
b): Electron micrograph of STZ-diabetic rat pancreas showing. (b) Damaged mitochondria (M), auotophagic vacuole (arrow head), dilated rough endoplasmic reticulum (arrows) and irregular contours of nuclei. Scale bar=1 lm.
(c) STZ+ Mfn-HCl group showing marked changes in pancreatic acini represented by damaged mitochondria (M), dilated rough endoplasmic reticulum, decrease of secretory granules (arrows) and cytoplasmic vacuolation. Scale bar=2 lm.
(d) STZ+ Mfn-HCl/Cr+3 showing marked improvement represented by increase in zymogen granules, regular contours of nuclei (N) and flattened rough endoplasmic (arrow heads) except few vacuoles. Scale bar=1 lm.
