Vaccinestrategy SIgA anti-FIV-p241 SIgA anti-HIV- gp1202 SIgG anti-FIV-p242 Week 2 Week 4 Week 6 Week 8 Week 8 Week 8 IM 1:256 1:32 1:16 1:4 1:512 1:4 IM Negative 1:4 1:16 Negative 1:256 Negative IM+ A(1-7) Negative 1:4 1:32 1:4 1:4,096 1:4 Topical gel only Negative 1:4 Negative Negative 1:163 Negative 0.1 mg A(1-7) Negative Negative 1:4 Negative 1:128 Negative 0.2 mg A(1-7) Negative Negative Negative Negative 1:128 Negative 0.3 mg A(1-7) Negative Negative Negative Negative 1:2,048 Negative 0.4 mg A(1-7) 1:256 1:4 Negative 1:16 1:128 1:16 5.0 mg A(1-7) 1:4 1:32 1:32 1:16 1:163 1:16 7.5 mg A(1-7) 1:16 Negative 1:32 1:512 Negative 1:128 10.0 mg A(1-7) Negative Negative Negative Negative Negative Negative

1Undiluted was the lowest dilution tested. Elution factor 4-fold 21:4 was the lowest dilution tested. Elution factor 4-fold 3Sample tested was from week 6.

Table 2: Oral secretory antibody titers.