Figure 4: Expression of FK506 binding protein (bp) and CD58 (lymphocyte function-associated antigen 3:LFA-3) receptors on the cell membrane of NOMO- 1 cell after application of S. sanguinis (BD113-20) antigen. FK506 bp, which combines immunosuppresive agent of FK506 (Tacrolimus), is composed of more than 20 proteins. It is known that some bacteria such as Legionella pneumophilla etc. via FK506bp of the cell membrane reduce the cytokine production from the macrophages after binding to calcineurin (CN) affecting the nuclear factor (NF- κB) of activated macrophage. (MAPK: mitogen-activated protein kinase).