Axis 1 Axis 2 Codon Value Aminoacid Codon Value Aminoacid CGG -0.334 Arg UCG -0.143 Ser CGA 0.289 Arg GUU 0.082 Val Axis 3 Axis 4 Codon Value Aminoacid Codon Value Aminoacid CUU 0.065 Leu UUA -0.142 Leu CUC 0.096 Leu CUU 0.097 Leu

Table 3: Position of codons in each of the four major axes of COA in CVB ORFs.