Figure 4: Schematic representation of α,β-tubulin dimer polymerization showing the allosteric relationship between the DDMC-paclitaxel complex and α,β-tubulin. Simplified structures are shown. A) α, β-tubulin dimer orientates with the active site (i.e., paclitaxel) of the DDMC-paclitaxel complex. The DDMC-paclitaxel complex (~270 nm) will consists of more than 8.1×103 DDMC molecules and 6.7×106 paclitaxel molecules.