Figure 2: Schematic representation of the intravascular strategies in subsets. A scheme depicts (1) approach with stenting (second-generation drug-eluting stent XIENCE V) proximal to the site of nano-intervention, (2) strategy with drug-coated balloon pre-dilatation of the target lesion at any site throughout the cap of the plaque with further nano-intervention, and (3) “no preparation” strategy when implantation of stent or balloon is not required. Upper panel shows coronary tree with a blue-painted target lesion and violet-painted site of PCI (either stent or balloon). A panel at the middle shows 3D-reconstruction of QCA (CAAS software, Pie Medical, The Netherlands) for the target lesion and utilized devices. Panel at the bottom demonstrates 3D-images of the relevant MSCT-scanning (QangioCT software, Medis, The Netherlands) with blue- and violet-painted target lesion and sites of the device intervention.