Figure 2: Schematic representation of αΒ-tubulin dimer polymerization showing the allosteric relationship between the DDMC–paclitaxel complex and αΒ-tubulin. Simplified structures are shown. A αΒ-tubulin dimer orientates with the active site (i.e., paclitaxel) of the DDMC–paclitaxel complex. The DDMC– paclitaxel complex (~270 nm) will consists of more than 8.1×103 DDMC molecules and 6.7×106 paclitaxel molecules.