Included Study Participant Intervention Outcome
Gross 1983 67 preterm infants
Gestation 27-33 weeks
Birth weight <1600g.
DBM (n=41) vs TFM (n=26) given as sole diet Suspected NEC: DBM(1/41) ; TFM(3/26)
Confirmed NEC: DBM(1/41) ; TFM(3/26)
Tyson 1983 81 preterm infants
Birth weight <1500g
DBM (n=37) vs PFM (n=44) given as sole diet Suspected NEC: DBM(0/37) ; PFM(2/44)
Confirmed NEC: DBM(0/37) ; PFM(1/44)
Cooper 1984 39 preterm infants
Gestation<36 weeks
Birth weight 1200-1500g
DBM (n=24) vs PFM (n=15)  given as sole diet Suspected NEC: DBM(1/24) ; PFM(3/15)
Confirmed NEC: DBM(1/24) ; PFM(3/15)
Lucas 1990A 159 preterm infants
Birth weight <1850g.
DBM (n=83) vs PFM (n=76) given as sole diet Suspected NEC: DBM(3/83) ; PFM(6/76)
Confirmed NEC: DBM(1/83) ; PFM(4/76)
Lucas 1990B 343 preterm infants
Birth weight <1850 g.
DBM (n=170) vs PFM (n=173) given as the supplement diet for EMM Suspected NEC: DBM(8/170) ;PFM(6/173)
Confirmed NEC: DBM(2/170) ;PFM(5/173)
Schanler 2005 173 preterm infants
Gestation 23-29 weeks
DBM (n=92) vs PFM (n=81) given as the supplement diet for EMM Suspected NEC: DBM(5/92) ; PFM(10/81)
Confirmed NEC: DBM(5/92) ; PFM(10/81)
Note: Lucas 1990A and Lucas 1990B were parallel studies in one trial. DBM: donor breast milk; TFM: term formula milk; PFM: preterm formula milk; EMM: expressed maternal milk; NEC: necrotizing enterocolitis.
Table 1: Characteristics of the included studies.