Figure 5: Different concentrations of polyphenols differentially altered expression of oxidative stress, cell cycle, and epigenome regulators. Cells were treated with vehicle or 12.5-50 μg/ml of polyphenols for 96 h and RNA was extracted. The mRNA levels were measured using real-time PCR as described in materials and methods. Data are reported as the mean ± SEM of relative gene expression normalized to control values of 3 independent experiments, each performed in triplicate. Means that do not share letters are significantly different from each other (FDR<0.05). A) Represents expression of the genes involved in cell cycle progression; B) Depicts expression of the epigenome modifiers; and C) Illustrates gene expression of the oxidative stress regulators.