Figure 5:Transcript levels of SREBPs and HMGCR and cholesterol effects on nuclear SREBP-2 levels in genistein-treated cells. mRNA levels of SREBP-2 (A), HMGCR (B) and SREBP-1c (C) in cells treated with 10 µM genistein for 24 h. Protein levels of LDLR, pre-SREBP-2, nuclear SREBP-2 and GAPDH in cells incubated with 10 µM of genistein in the presence of either cholesterol (5 µg/ml) or solvent alone (0.1% ethanol) for 24 h (D).