Groups CK-MB(U/L) LDH(IU/L) ALT(IU/L) AST (IU/L)
Normal (1 ml saline) 63.46 ± 4.65 126.45 ± 7.43 25.16 ± 2.30 32.64 ± 3.40
Control (ISO, 85 mg/kg) 526.75 ± 11.37* 243.85 ± 9.44* 42.66 ± 1.35* 57.33 ± 4.11*
Astaxanthin (50 mg/kg) + ISO (85 mg/kg) 282.25 ± 10.55@ 205.61 ± 11.36@ 35.18 ± 2.40@ 46.22 ± 3.53@
Astaxanthin (100 mg/kg) + ISO (85 mg/kg) 210.30 ± 9.86* 143.56 ± 7.18* 28.24 ± 3.06* 37.48 ± 3.50*
Vitamin C (1 g/kg,b.w) + ISO (85 mg/kg) 235.12 ± 7.65* 152.33 ± 9.40* 31.25 ± 1.53* 40.64 ± 2.57*
Isoproterenol was given subcutaneously as a single dose of 85 mg/kg.b.w. to 18 h fasted animals. It was given to all groups except the normal one. astaxanthin (50 and 100 mg/kg) were orally given daily for 58 days and the last dose of each was given 1 h before Isoproterenol administration. Blood samples were collected 24 h after isoproterenol administration. Values are given as mean ± SD for groups of eight animals each.
* Significantly different from normal group at p<0.01. @ Significantly different from control group at p< 0.05.
Table 3: Level of plasma CK-MB, LDH, ALT and AST in normal and experimental groups of rats.