| Groups |
TBARS |
HP |
| Heart (mM/100 g of tissue) |
Plasma (nM/ml) |
Heart
(mM/100 g of tissue) |
Plasma
(mM/dL) |
| Normal (1 ml saline) |
1.25 ± 0.12 |
1.64 ± 0.23 |
2.56 ± 0.35 |
3.65 ± 0.54 |
| Control (ISO, 85 mg/kg) |
2.10 ± 0.47* |
3.20 ± 0.18* |
4.84 ± 0.42* |
5.25 ± 0.36* |
| Astaxanthin (50 mg/kg) + ISO (85 mg/kg) |
1.83 ± 0.23@ |
2.46 ± 0.29@ |
3.30 ± 0.25@ |
3.94 ± 0.18@ |
| Astaxanthin (100 mg/kg) + ISO (85 mg/kg) |
1.40 ± 0.35* |
1.97 ± 0.24* |
2.44 ± 0.46* |
3.50 ± 0.22* |
| Vitamin C (1g/kg,b.w) + ISO (85 mg/kg) |
1.66 ± 0.23* |
2.35 ± 0.31* |
2.75 ± 0.11* |
3.79 ± 14.27* |
Isoproterenol was given subcutaneously as a single dose of 85 mg/kg.b.w. to 18 h fasted animals. It was given to all groups except the normal one. astaxanthin (50 and
100 mg/kg) were orally given daily for 58 days and the last dose of each was given 1 h before Isoproterenol administration.. Values are given as mean ± SD for groups of
eight animals each.
* Significantly different from normal group at p<0.01. @ Significantly different from control group at p<0.05. |
