Figure 4: Free glutamate stimulates gastric secretion via vago-vagal reflex. Supplementation with 100 mM monosodium L-glutamate (MSG) enhanced gastric secretion induced by a high-caloric amino acid-rich diet, but did not affect secretion induced by a carbohydrate-rich amino acid-free diet in Pavlov pouch dogs. A) Secretion of acid, pepsinogen and fluid in the small gastric pouch stimulated with an amino acid-rich diet (Elental diet). B) Secretion in the small gastric pouch induced by 100% dextrin, amino acid-free diet. Both diets were infused through a fistula into the main stomach and secretions were measured in the washes from the Pavlov pouch. Data are expressed as mean±SEM. Infusion of each diet are marked with arrows. Paired comparisons were made with Student’s t test; * : p_0.05, ** : p_0.01; n=9 in each group. Data are quoted from ref. 28. Data are quoted from Zolotarev et al. [37].