Time of Evaluation # of Subjects w/Active‡ Hair Dryness Hair Dullness Nail Hardness Nail Splitting Nail Peeling Skin Dryness/Face 8 weeks 10 80 90 100 80 90 60 6 months 8 88 100 88 88 88 50 9 months 8 100 100 88 75 100 75 12 months 8 100 88 88 75 100  ---¶

† To be included in the moderately-severe to severe categories, participants were rated in the 7-10 range initially on a scale similar to the one shown in “Figure 1.” A significant change was defined to be a 2-point or greater improvement. ‡ There were 10 participants in the active group and 10 participants in the control group at the start of each study but only 8 participants completed the study as two were relocated for employment reasons.

¶ Skin dryness was only evaluated for 9 months (and no cross-over data is available) because participants were unwilling to refrain from using sunblock during the summer months.

Table 3: Percent of Subjects Taking Active Ingredients with Significant Changes† from Baseline when starting with Moderately-severe to Severe Problems (60-week crossover study).