Week 4 Week 8 Week 14 Week 20 Week 26 Week 34 Week 38 Week 44 Week 52 Crossoverto vehicle + 8 wks Hair Dryness A 33 36 41 34* 40† 42† 43† 43† 42† 3†   P -5 -5 2* -3* 5* 6† 6‡ 5‡ -1‡ 27‡ Hair Dullness A 33 37 43 43* 37† 44† 42† 39† 38† 14†   P 10 7 9* -3* 7* 14† 1‡ -2‡ 11‡ 35‡ Nail Hardness A 32 46 47 33* 42† 42† 43† 31† 25† 18†   P 1 -2 4* 6* 16* 14† 16† 9‡ -1‡ 35‡ Nail Splitting A 74 78 81 74* 67† 88† 71† 72† 54† 39†   P -2 7 17* -6* 7* 16† 17‡ 4‡ 12‡ 95‡ Nail Peeling A 73 91 84 95* 84† 94† 10† 98† 90† 73†   P -4 11 14* 30* 42* 45† 64‡ 43‡ 43‡ 95‡ Skin Dryness A 20 32 36 20* 23† 36† ¶ ¶ ¶ ¶   P -3 -3 4* 13* 20* 14† ¶ ¶ ¶ ¶

Table 4: A Comparison of Active to Placebo: Percent of Improvement From Baseline (60-week crossover study). A=Active; P=Placebo *(9 subjects); †(8 subjects);‡(7 subjects) ¶ Skin dryness was only evaluated for 9 months (and no cross-over data is available) because participants were unwilling to refrain from using sunblock during the summer months.