| Commercial Platform |
Most Frequent Error Type |
Error Frequency |
| Capillary sequencing |
single nucleotide substitutions |
10-1 |
| 454 GS Junior |
Deletions |
10-2 |
| PacBio RS |
CG deletions |
10-2 |
| Ion Torrent PGM |
Short deletions |
10-2 |
| Solid |
A-T bias |
2 x10-2 |
| IlluminaMiSeq |
single nucleotide substitutions |
10-3 |
| Illumina HiSeq2000 |
single nucleotide substitutions |
10-3 |
| Tag-based methods: |
|
|
| SafeSeq |
single nucleotide substitutions |
1.4 x 10-5 |
| CircleSeq |
single nucleotide substitutions |
7.6 x 10-6 |
| Duplex Sequencing |
Single nucleotide substitutions |
5 X 10-8 |