Gene header UniprotAcc. Gene name Log2FC FC
Down-regulated genes in deformed vertebra
comp149051_c0 A4IFW2 Protein tyrosine phosphatase receptor type F 1.64 3.12
comp138459_c1 Q64487 Protein tyrosine phosphatase receptor type D 1.62 3.08
comp145566_c4 Q96JQ0 DachsousCadherin-Related 1 1.55 2.93
comp144178_c2 Q6ZRS2 Snf2-related CREBBP activator protein 1.49 2.8
comp146067_c0 P35556 Fibrillin 2 1.42 2.67
comp132718_c0 P45481 CREB bindingprotein 1.38 2.61
comp149014_c5 Q8BNA6 FAT atypicalcadherin 3 1.37 2.59
comp144153_c0 O95644 Nuclear factor of activated T-cells, calcineurin-dependent 1.31 2.49
comp133481_c0 Q9Y3S1 Serine/threonine-protein kinase WNK2 1.31 2.49
comp148107_c0 Q8WYB5 K (Lysine) acetyltranferase 6B 1.24 2.35
comp147565_c0 Q5I598 Methylenetetrahydrofolate (NAD(P)H) 1.22 2.33
comp143062_c0 Q13332 Protein tyrosine phosphatase receptor type S 1.19 2.28
comp126856_c0 P17948 Vascular endothelial growth factor receptor 1 1.17 2.24
comp134803_c0 Q14517 FAT atypicalcadherin 1 1.14 2.21
comp143303_c7 Q8VI24 SATB homeobox 2 1.12 2.18
comp145538_c0 Q99715 Collagen type X2 alpha 1 1.12 2.18
comp131699_c0 F1QCC6 Glypican 1 1.1 2.14
comp146160_c1 Q9Z180 SET bindingprotein 1 1.1 2.14
comp149571_c0 Q9P2D1 Chromodomain helicase DNA binding protein 1.09 2.13
comp140581_c1 Q92794 K (Lysine) acetyltranferase 6A 1.05 2.07
comp128868_c0 O75581 Low density lipoprotein receptor-related protein 6 1.04 2.05
comp142199_c3 O70496 Chloridechannel voltage-sesitive 7 1.01 2.01
comp147156_c2 O89026 Roundabout axon guidance receptor homolog 1 0.97 1.96
comp135768_c0 P27658 Collagen type VIII Alpha 1 0.97 1.97
comp149750_c0 Q6V0I7 FAT atypicalcadherin 4 0.97 1.96
comp134251_c0 Q8BTM8 Filamin A, alpha 0.97 1.96
comp141372_c4 P98161 Polycystin 1 0.95 1.93
comp144389_c0 A7XYQ1 Jackson circlerprotein 1 0.94 1.92
comp67973_c1 Q6NSM8 SIK family kinase 3 0.93 1.91
comp135751_c0 Q9UBS9 Sun domain-containing ossification factor 0.93 1.9
comp135751_c0 Q9QYP0 Multiple EGF-like-domain 8 0.91 1.88
comp145151_c0 P26012 Integrin β 8 0.9 1.87
comp136915_c0 Q13233 Mitogen-activated protein kinase kinasekinase 1 0.89 1.85
comp149523_c0 O88491 Nuclear receptor binding SET domain protein 1 0.87 1.83
comp149485_c0 Q9UHF7 Trichorhinophalangeal syndrome I 0.87 1.83
comp139497_c0 P21359 Neurofibromin 1 0.86 1.81
comp149389_c0 O35607 Bone morphogenetic protein receptor, type II 0.85 1.81
comp146007_c0 Q14938 Nuclear factor 1/X (CCAAT-binding transcription factor) 0.85 1.8
comp146819_c2 Q90413 Fibroblastgrowth factor receptor 4 0.81 1.75
comp146502_c4 P20909 Collagen type XI alpha 1 0.8 1.74
comp149588_c0 A2A884 Human immunodeficient virus type 1 enhancer binding protein 3 0.79 1.73
comp147279_c4 P98160 Heparan sulfate proteoglycan 2 0.78 1.72
comp144268_c0 Q09472 E1A bindingprotein P300 0.78 1.71
comp149387_c2 Q8IXJ9 Additionalsexcombslike 1 0.78 1.71
comp148958_c0 Q9ULT8 HECT domaincontaining E3 ubiquitinprotein ligase 1 0.78 1.71
comp149573_c0 P10587 Myosin heavy chain 11 smooth muscle 0.77 1.71
comp149223_c0 P79114 Unconventional myosin-X, role n podosom belt osteoclast 0.77 1.7
comp149584_c1 P35580 Myosin  10 0.75 1.68
comp138258_c6 Q07889 Son of sevenlesshomolog 1 0.69 1.61
comp147381_c0 Q91YM2 Rho GTPaseactivatingprotein 35 0.68 1.6
Up-regulated genes in deformed vertebra
comp146739_c2 Q9YHV3 Noggin-3 -3.19 9.13
comp142082_c0 P57102 Heart and neural crest derivatives expressed 2 -1.84 3.59
comp148652_c4 Q9JK00 Sodium channel voltage gated type III β subunit -1.63 3.09
comp149418_c1 P05549 Activating Enhancer-Binding Protein 2-Alpha -1.51 2.84
comp142563_c0 P09238 Matrix metallopeptidase 10 -1.46 2.76
comp88970_c0 P79703 Jun B proto-oncogene -1.42 2.67
comp144447_c2 Q05826 CCAAT/Enhancerbindingprotein (C/EBP) Β -1.27 2.42
comp135507_c0 Q920D2 Dihydrofolatereductase -1.26 2.4
comp146593_c0 P40148 Osteocalcin -1.13 2.19
comp144817_c0 O75911 Dehydrogenase/Reductase (SDR family member 3) -0.93 1.9
comp121895_c0 Q800Y2 Matrix Glaprotein -0.86 1.82
comp136344_c0 P52909 Jun D proto-oncogene -0.85 1.8
comp148539_c0 P70061 NK3 homeobox 2 -0.85 1.81
comp147786_c0 Q92008 Sonichedgehog -0.84 1.79
comp143712_c0 P25942 CD40 molecule TNF receptor family member 5 -0.78 1.72
comp149526_c0 Q9NRR1 Cytokine-Like 1 -0.78 1.71
comp141960_c0 P97831 Twist 2 -0.75 1.69
comp98891_c0 O55052 Macrophage migration inhibitory factor -0.7 1.62
comp148620_c0 P18203 FK506 binding protein 1A, 12kDa -0.7 1.63
Table 1: Selection of differentially-expressed genes putatively related to bone metabolism. The homologies were revealed with blast-x search against Uniprot-Swissprot database (cut-off evalue<1e-8). Differentially expressed genes were conserved if they display a unique and FDR<5%.