| Figure 2: In vitro drug release of lomustine as function of component variables.
(A) Release of lomustine, batches APL and APL1, and APL2 as a function of
PLA concentration. (B) Release of lomustine, batches APL, APL3, and APL4
as a function of lomustine concentration, (C) Release of lomustine, batches
APL and APL5 as a function of aqueous phase (PVA solution) amount, (D)
Release of lomustine, batches APL, APL6-7 as a function of PVA solution
concentration, (E) Release of lomustine batches APL, APL8 as a function of
PVA incorporation mode (F) Release of lomustine, batches APL10-12 as a
function of co-solvent ethanol addition. (G) Release of lomustine, batches APL,
APL13-14 as a function of organic solvent evaporation condition, (H) Release
of lomustine, batches APL, APL15-19 as a function of homogenization speed
and time. |
Bars represent ± SD (n=3)