S.No

Formulation Batch code

PLA
(mg)

Lomus-tine
(mg)

Acetone
(ml)

50ml PVA solution (%w/v)

Ethanol (ml)

Particle Size (nm)
(Mean ± SD)*

PDI
(Mean ± SD)*

*Drug content (mg)

Encapsulation efficiency
(Mean ± SD)*

1.

APL

200

10

20

1%w/v

-

115 ± 1.2

0.13 ± 0.001

7.9

79 ± 0.18%

2.

APL1

100

10

20

1%w/v

-

68 ± 0.89

0.06 ± 0.008

4.7

47 ± 0.23%

3.

APL2

300

10

20

1%w/v

-

137 ± 0.94

0.18 ± 0.004

9.0

90 ± 0.34%

4.

APL3

200

20

20

1%w/v

-

122 ± 1.6

0.22 ± 0.003

13.8

69 ± 0.07%

5.

APL4

200

30

20

1%w/v

-

128 ± 0.75

0.25 ± 0.001

21.9

73 ± 0.14%

6.

APL5

200

10

20

100ml1%w/v

-

117 ± 0.63

0.1 ± 0.001

8.5

85 ± 0.37%

7.

APL6

200

10

20

2%w/v

-

125 ± 0.92

0.086 ± 0.017

8.3

83 ± 0.08%

8.

APL7

200

10

20

3%w/v

-

130 ± 0.78

0.092 ± 0.006

8.8

88 ± 0.15%

9.

APL8

200

10

20

1%w/v

-

136 ± 0.99

0.085 ± 0.004

8.1

81 ± 0.06%

10.

APL9

200

10

20

1%w/v

-

Unstable

-

-

-

11.

APL10

200

10

20

1%w/v

1

123 ± 0.76

0.074 ± 0.007

8.4

84 ± 0.19%

12.

APL11

200

10

20

1%w/v

2

117 ± 1.1

0.079 ± 0.004

8.8

88 ± 0.24%

13.

APL12

200

10

20

1%w/v

3

75 ± 1.6

0.083 ± 0.002

9.3

93 ± 0.17%

14.

APL13

200

10

20

1%w/v

-

133 ± 1.4

0.081 ± 0.016

8.6

86 ± 0.26%

15.

APL14

200

10

20

1%w/v

-

110 ± 0.83

0.088 ± 0.003

9.5

95 ± 0.31%

16.

APL15

200

10

20

1%w/v

-

844 ± 1.6

0.30 ± 0.018

5.5

55 ± 0.19%

17.

APL16

200

10

20

 1%w/v

-

799 ± 1.8

0.27 ± 0.012

6.2

62 ± 0.26%

18.

APL17

200

10

20

1%w/v

-

437 ± 0.87

0.23 ± 0.001

6.6

66 ± 0.23%

19.

APL18

200

10

20

1%w/v

-

238 ± 0.65

0.19 ± 0.004

7.2

72 ± 0.34%

20.

APL19

200

10

20

1%w/v

-

100 ± 1.0

0.066 ± 0.003

8.9

89 ± 0.25%