Figure 1: Illustration and photograph of the flow-focusing device used for rifampicin nanoprecipitation. (a) scheme indicating anti-solvent nanoprecipitation process. Rifampicin is focused using water flow on side channels to create a narrow stream in the diffusion region. The solvent (Methanol) diffuses in water (y direction) promoting rifampicin supersaturation in the diffusion region (x direction). (b) Glass microfluidic system, with 110 μm-wide side channels and 100μm-wide central channel, both having 80 μm in depth.