Figure 1: (a) HRSEM images of siRNA nanoparticles formed within 1 min of sonication time and (b) within 3 min sonication time. The corresponding STEM images of siRNA nanoparticles are shown in the right corner of each image. Scale bars=100 nm; (c) diagram for the mechanism of sonochemical siRNA nanoparticles formation resolved from MD simulations of siRNA molecules in water; (d) size distribution (obtained from DLS analysis) histogram for free siRNA molecules, siRNA nanoparticles created within 1, 3 and 5 min sonication time. The exact are shown in Supportin Information.