Figure 4: In vitro PTX release of redox-responsive polymer: (
) poly(AMPD-BAC)-g-PEG-lipoyl-PTX incubated with 20 M DTT; (
) poly(AMPD-BAC)-g-PEG-lipoyl-PTX-MMP2 incubated with 20 M DTT; (
) poly(AMPD-BAC)-g-PEG-lipoyl-PTX-MMP2 incubated with 20 M DTT
and MMP-2 enzyme. All tests were performed in triplicates. |