Figure 3: ((a) Cumulative release of poly(AMPD-BAC)-g-PEG-DTPA-Pt in water ( ) and in chloride solution (150 mM NaCl) ( ). There is no significant release of platinum complex in either water or high chloride solution which is mainly attributed to the strong chelation of DTPA. (b) Effects of poly(AMPD-BAC)- g-PEG, poly(AMPD-BAC)-g-PEG-DTPA-Pt and cisplatin on viability of MCF-10A after 24 h incubation. Poly(AMPD-BAC)-g-PEG-DTPA-Pt shows little cytotoxicity to cells as poly(AMPD-BAC)-g-PEG. Cytotoxicity profile of cisplatin is presented for comparison. Optical images of MCF-10A cells 24 h incubation with 10 mg/mL concentrations of (c) Poly(AMPD-BAC)-g-PEG, (d) Poly(AMPD-BAC)-g-PEG-DTPA-Pt and (e) cisplatin.