Figure 4: (A) A quantitative proteomic approach based on stable isotopic labeling by amino acids in cell culture (SILAC) identified a set of de-regulated proteins upon Ch-SeNPs exposure. (B) Altered proteins were involved in cell cycle regulation (RCC), cellular compromise (CC), cellular growth and proliferation (CGP), amino acid metabolism (AAM) and cell morphology (CM). Among these found de-regulated proteins, several subunits of the eIF3 protein complex, involved in the protein synthesis machinery, appeared downregulated after Ch-SeNPs exposure.